There are several laboratory tests that may be performed to investigate hypercoagulable states, including:
- Prothrombin time (PT) and activated partial thromboplastin time (aPTT) - to evaluate the extrinsic and intrinsic pathways of coagulation
- D-dimer test - to detect the presence of fibrin degradation products, which are indicative of clot formation
- Fibrinogen level - to evaluate the level of the primary clotting protein
- Factor VIII and von Willebrand factor - to evaluate levels of clotting factors that are important in the intrinsic pathway
- Antithrombin III (ATIII) - to evaluate levels of an inhibitor of clotting
- Protein C and protein S - to evaluate levels of clotting inhibitors that are dependent on vitamin K
- Lupus anticoagulant and anticardiolipin antibodies - to evaluate for the presence of antibodies that can cause hypercoagulability
- Factor V Leiden and prothrombin G20210A mutations - to evaluate for genetic predisposition to hypercoagulability.
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